Syringes

ZEONEX^® and ZEONOR^® Cyclo Olefin Polymers

Advanced Polymer Resin for Medical Precision

Zeon’s Medical-Grade Cyclo Olefin Polymer (COP) resins for molding high-performance injectables ensure exceptional strength, clarity, and drug compatibility for critical healthcare applications. Medical-grade resins ZEONEX^® 690R, 790R, 5000 and ZEONOR^® 1020R have been assessed for compliance with USP Class VI and <661.1>, ISO 10993, and JP and EU standards. Drug master file information is available upon request.

Product Information

Low Protein Adsorption and Aggregation

ZEONEX^® and ZEONOR^® COP are optimal for long-term storage of protein and peptide-based biopharmaceuticals. Compared to glass and polypropylene, ZEONEX^® and ZEONOR^®COP's low zeta potential and inert surface result in very little protein adsorption. Elimination of silicone oil from the syringe barrel further reduces adsorption and potential protein aggregation. ZEONEX^® and ZEONOR^® COP do not contribute to pH shift of the diluent, common with glass, thus reducing the chance for protein precipitation

Technical Data Sheet

Line graph showing protein adsorption of Abatacept on glass or ZEONEX® 690R syringes. X-axis: concentration (mg/mL). Y-axis: protein adsorbed (mg/m²).

Durability

ZEONEX^® and ZEONOR^® COP excel for drug storage devices where there is breakage risk. Compared to glass and Polypropylene (PP), syringes made from Zeon's Cyclo Olefin Polymers exhibit superior impact strength over a wide range of temperatures, including cryogenic storage conditions (-194 °C). ZEONEX^® and ZEONOR^® are also mechanically tough and withstand increased stress from injecting viscous drug formulations or from auto-injector syringes with high injection forces.

Low moisture permeability

ZEONEX^® and ZEONOR^® COP demonstrate a high moisture barrier property compared to conventional polymers. This barrier minimizes evaporation during storage, maintaining stable reagent concentrations. The barrier provided by ZEONEX^® and ZEONOR^® also helps prevent degradation of moisture-sensitive compounds, extending the shelf life of pharmaceuticals.

Sterilization compatibility

ZEONEX^® and ZEONOR^® COP Syringes are compatible with EtO, Gamma irradiation, peroxide, and steam/autoclave* sterilization methods. Compared to other plastics, ZEONEX^® and ZEONOR^® have lower post-sterilization haze, enabling easier visual inspection of syringe contents. The material strength and durability are also maintained post-sterilization.

*Grades ZEONEX^® 690R and 790R are compatible with steam/autoclave sterilization

Manufacturing

ZEONEX^® and ZEONOR^® COP have excellent injection molding properties, suitable for standard geometries as well as precision micro-molding. The superior mechanical strength and flexural modulus of ZEONEX^® and ZEONOR^® COP make it ideal for manufacturing complex designs, such as in Wearables, that have a high risk of breakage when releasing from the mold.

Industries

Precision Polymer for Unmatched Performance

We’ve got what you need – premium resins that power innovation, support compliance and improve product performance for major companies in Pharma, Medtech, Research, and Diagnostic sectors.