Diagnostic and Life Sciences Cyclo Olefin…

Diagnostic Grade ZEONOR^® Advantages

ZEONOR^® Cyclo Olefin Polymer (COP) Resins enable precision-molded, next-generation diagnostics and microfluidics without risk of extractables interfering with results. The inert chemistry and high purity of ZEONOR^®COP offers an exceptional platform for performing cell growth and cell-based assays.

Glass-like transparency
Low autofluorescence
Low residual metals
Low extractables and leachables
Low protein absorption
Chemical compatibility with most reagents

Exceptional Moldability

ZEONOR^® Cyclo Olefin Polymer’s high melt flow rates enable precise manufacturing of microstructures and other fine features in complex designs. ZEONOR^® 1430R is specially formulated with a low molecular weight to give higher flow during injection or compression molding. Uniformly high aspect ratio structures with sharp edges and corners can be replicated over wide arrays.

A close-up image of microfluidics diganostics

Bar chart of detectable metal content in medical-grade polymers measured by ICP-MS. X-axis: compares Polypropylene (249,700), Polystyrene (64,000), COC (195) , and Zeonex 1420R (7) Y-Axis: Total detectable metals (ng/g)

High Purity

ZEONOR^®COP is more pure than other plastics (polypropylene; polystyrene) commonly found in diagnostic consumables. ZEONOR^® resins contain less-than-detectable residual metals and there are no additives or process aids.

Low Protein Adsorption

ZEONOR^® COP’s low surface energy minimizes the adsorption of proteins. In diagnostics and microfluidics with high surface area to volume ratios, and in assays with very low levels of analytes, the loss of precious materials is minimized.

High Solvent Compatibility

ZEONOR^® COP is compatible with most alcohols, acids and bases. Commonly-used reagents in the Life Sciences do not affect the optical clarity or mechanical strength of the resin.

Interference-Free Results

Molecular diagnostics and point of care (POC) testing rely on fluorescence-based assays for detection and quantification of biomarkers used for identifying pathogens and viral load monitoring. A diagnostic test’s detection sensitivity can be depressed and accuracy compromised by polymer materials that contribute background signals. ZEONOR^® COP offers the combination of unsurpassed low fluorescence and high optical transmission, enabling high signal-to-noise for highly sensitive assays.

Technical Highlights

	Units	ZEONOR^® 1020R	ZEONOR^® 1060R	ZEONOR^® 1420R	ZEONOR^® 1430R
Properties
Melt flow rate (MFR) (280 ⁰C, 21.18 N)	g/10min	18.2	12.6 (230 ⁰C)	16.9	30
Glass transition temparature	⁰C	101.7	98.8	136	134.5
Light transmittance (3 mm thickness)	%	91.5	91.5	91.5	91.5
Water absorption (23 ⁰C/24 hrs)	%	0.01	0.01	0.01	0.01
Performance
Extractables and leachables		Low	Low	Low	Low
Alcohol compatibility		Good	Good	Good	Good
Acid/Base compatibility		Good	Good	Good	Good
Pharmaceutical Storage Compatibility
Pharmacopeia registerred		Yes	No	No	No

Applications

Engineered to Perform

Red Liquid being placed into a microplate for testing

Microplates

ZEONOR^® COP’s low autofluorescence reduces optical noise in microplates, improving accuracy in diagnostics and assays. Low coefficient of thermal expansion enables flat, uniform plates.

Diagnostic Consumables

ZEONOR^®’s ultra-low autofluorescence enables extremely sensitive diagnostic assays.

Microfluidic Devices

Low non-specific binding of protein and cells to ZEONOR^® COP is critical for operations that use only microliters of sample.

Certifications

Our certifications affirm our commitment to Quality and Compliance. Our factories are certified for ISO 9001 and 14001, representing world-class standards for Quality and Environmental considerations. Our Medical and Diagnostic Grade ZEONOR^® 1020R COP resin is compliant with USP Class VI and <661.1>, with FDA Drug Master Files available upon request, representing our commitment to providing materials that meet the strictest performance standards.